Pharmaceutical Intermediate 4 Methylimidazole 1H Imidazole 4 Methyl Purified

Pharmaceutical Intermediate 4 Methylimidazole 1H Imidazole 4 Methyl Purified

4-MeI may be prepared using the Debus-Radziszewski imidazole synthesis, by reacting methylglyoxal with ammonia and formaldehyde. It may also be prepared by the reaction of hydroxyacetone and formamide in ammonia.

Small energy difference separates 4-methylimidazole from its tautomer 5-methylimidazole.

4-Methylimidazole (4-MeI or 4-MEI) is a heterocyclic organic chemical compound with molecular formula H 3C–C 3H 3N 2 or C 4H 6N 2. It is formally derived from imidazole through replacement of the hydrogen in position 4 by a methyl group. It is a slightly yellowish solid.
4-MeI may be formed in the browning of certain foods through the Maillard reaction between carbohydrates and amino-containing compounds. In particular, it is found in roasted foods, grilled meats, coffee and in types of caramel coloring produced with ammonia-based processes. It may arise also by fermentation.

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